Kinase Wee1 fusion protein compositions, nucleotide...

Details Kinase Wee1 fusion protein compositions, nucleotide... Kinase Wee1 fusion protein compositions, nucleotide...

2007-06-05

2007-06-05

Prouty, Rebecca (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

C435S007100, C435S007600, C435S194000

Reexamination Certificate

active

10375214

ABSTRACT:
The invention describes recombinant fusion proteins containing Wee1 protein sequences involved in checkpoint regulation of cell cycle, nucleic acid molecules that encode the fusion protein, and methods using the proteins for screening for compounds which modulate Wee1 or Cds1 function.

REFERENCES:
R. Aligue et al., “Regulation of Schizosaccharomyces pombe Wee1 Tyrosine Kinase”, J. Biol. Chem. 272(20):13320-13325. (May 1997).
Honda, et al. Mouse p87wee1 Kinase is Regulated by M-Phase Specific Phosphorylation.Chromosome Res., 3(5): Aug. 1995. 300-308.
Honda, et al. 14-3-3 Zeta Protein Binds to the Carboxyl Half of Mouse Wee1Kinase.Biochem. Biophys. Res. Commun. 230: Jan. 1997. 262-265.
Tang, et al. Two Distinct Mechanisms for Negative Regulation of the Wee1 Protein Kinase.EMBO J. 12(9): Sep. 1993. 3427-3436.

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