Kinase peptides and antibodies

Details Kinase peptides and antibodies Kinase peptides and antibodies

2008-04-08

2008-04-08

Le, Long V. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007200, C435S007910, C435S007920, C436S518000, C530S387100

Reexamination Certificate

active

07354725

ABSTRACT:
The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of a kinase-mediated disease, as well as for determining or monitoring the efficacy of treatment.

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Wadsworth, et al., “RWJ 67657, a Potent, Orally Active Inhibitor of p38 Mitogen-Activated Protein Kinase”; J. Pharmacol & Experimental Therapeutics; (1999) 291: 680-687.
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Clifton, et al.; “A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress”;FEBS Letts.; (1996); 392: 209-214.
Leighton, et al.; “Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation”;FEBS Ltts.; (1995); 375: 289-293.
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Search Report dated May 17, 2006.

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