Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-04-22
2011-12-13
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S252160, C544S277000, C544S238000, C544S363000
Reexamination Certificate
active
08076338
ABSTRACT:
The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
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Anand Neel K.
Bannen Lynne Canne
Blazey Charles M.
Bowles Owen Joseph
Bussenius Joerg
Exelixis Inc.
McDonnell Boehnen & Hulbert & Berghoff LLP
Sackey Ebenezer
Wilson James O
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