Kinase inhibitors

Details Kinase inhibitors Kinase inhibitors

2007-03-27

2007-03-27

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S256000

Reexamination Certificate

active

10621983

ABSTRACT:
This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula:that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.

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Adachi, K., “Synthesis of Orcinol Monomethl Ether”, Memoirs of the Osaka Institute of Technology, Series A, 1983 pp. 33-42, vol. 28, No. 1.

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