Kinase in TGF-.beta. family signal transduction system

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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536 235, 530350, 435194, 435183, 4352251, 4352252, C12N 1500

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active

059453010

ABSTRACT:
The invention relates to a kinase which is activated by transforming growth factor-.beta. (TGF-.beta.) and funstions in the TGF-.beta. family signal tranduction system. The invention further relates to a process of producing said kinase and to a gene encoding said kinase.

REFERENCES:
Shibuya et al, "Is AMK-1 a transfer molecule involved in TGF-.beta. signal transduction," 68th Meeting of Japanese Biochemical Society, Sep. 15-18, 1995, Sendai, Japan (including English translation);.
Nishida et al, "Signaling pathways and functions of the MAP kinase superfamily," Proceedings of the Japanese Cancer Association , 54th Meeting of Japanese Cancer Association, Oct. 3-5, 1995, Kyoto, Japan (including English translation);.
Irie et al, "A novel member of MAPKKK, TAK1, may function as a mediator in TGF-.beta. signal transduction," 18th Meeting of Japanese Molecular Biology Association, Dec. 6-9, 1995, Nagoya, Japan (including English translation);.
Yamaguchi et al, "Role of TAK1 kinase and its activator TAB1 in the TGF-.beta. signaling pathway," 18th Meeting of Japanese Molecular Biology Society, Dec. 6-9, 1995, Nagoya, Japan (including English translations);.
Yamaguchi et al "Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-.beta. Signal Transduction," Science, vol. 270 (Dec. 22, 1995) pp. 2008-2011.
George et al., Macromolecular Sequencing and synthesis, Selected Methods and applications, pp. 127-149, Alan R. Liss, Inc., 1988.

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