Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1997-11-21
2000-10-24
Pronty, Rebecca E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
4353201, 435325, 4352523, 435 6, 536 232, 536 231, C12N 912, C12N 1500, C12Q 168, C07H 2102
Patent
active
061365815
ABSTRACT:
The specification describes isolated, purified, or enriched nucleic acid molecules which correspond to particular genes encoding kinases, and to fragments of such genes, as well as the polypeptides encoded by such nucleic acids and antibodies specific for those polypeptides. Also disclosed are methods using such nucleic acid molecules, polypeptides, or antibodies for isolating the full coding sequences for those kinases, for determining the expression patterns and levels for those genes, for screening for agents which modulate the activity of one of the kinases, and for diagnosing or treating a disease associated with one of the kinases.
REFERENCES:
patent: 4945050 (1990-07-01), Sanford et al.
Aaronson, "Growth Factors and Cancer," Science 254:1146-1153 (1991).
Adams M D et al: "Initial Assessment of Human Gene Diversity and Expression Patterns Based Upon 83 Million Nucleotides of cDNA Sequence," Nature, London, GB, 377:3-7 Sep. 28, 1995).
Adams, et al., EMBL Sequence Database, Heidelberg DE, XP002062967, accession nr.: AA322346, Apr. 1997.
Atshul et al., "Basic Local Alignment Search Tool," J. Mol. Biol. 215:403-410 (1990).
Anostario, M. Jr. et al., "Immunochemical Detection of Adenine Nucleotide-Binding Proteins with Antibodies to 5'-p-Fluorosulfonylbenzoyladenosine," Anal. Biochem. 190, 60-65, 1990.
Ausubel et al., Current Protocols in Molecular Biology (Index), John Wiley and Sons, (1994).
Bayer et al., "The Avidin--Biotin Complex in Affinity Cytochemistry," Meth. Enzym. 62:308 (1979).
Benoist and Chambon, "In Vivo Sequence Requirements of the SV40 Early Promoter Region," Nature 290:304-310 (1981).
Bishop, "Molecular Themes in Oncogenesis," Cell 64:235-248 (1991).
Bollon, et al., "DNA Transformation Efficiency on Various Bacterial and Yeast Host-Vector Systems," J. Clin. Hematol. Oncol. 10:39-48 (1980).
Botstein, et al., "Making Mutations In Vitro and Putting Them Back Into Yeast," From Gene to Protein: Translation Into Biochemistry, Miami Wntr. Symp. 19:265-274 (1982).
Brinster et al., "Factors Affecting the Efficiency of Introducing Foreign DNA into Mice by Microinjecting Eggs," Proc. Natl. Acad. Sci. USA 82:4438-4442 (1985).
Broach, "The Yeast Plasmid 2u Circle," Cell 28:203-204 (1982).
Broach, In: The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, p. 445-470 (1981).
Bullock et al., Techniques in Immunocytochemistry, Academic Press, Orlando, FL vol. 1 (1982), vol. 2 (1983), vol. 3 (1985).
Campbell, "Monoclonal Antibody Technology: Laboratory Techniques in Biochemistry and Molecular Biology", Elsevier Science Publishers, Amsterdam, The Netherlands (1984).
Capecchi, "Altering the Genome by Homologous Recombination," Science 244:1288-1292 (1989).
Capecchi, MR, "High Efficiency Transformation by Direct Microinjection of DNA into Cultured Mammalian Cells," Cell 22:479-88 (1980).
Carraway and Cantley, "A Neu Acquaintance for ErbB3 and ErbB4: A Role for Receptor Heterodimerization in Growth Signaling," Cell 78:5-8 (1994).
Cenatiempo, "Prokaryotic Gene Expression In Vitro: Transcription-Translation Coupled Systems," Biochimie 68:505-516 (1986).
Chard, "An Introduction to Radioimmunoassay and Related Techniques" Elsevier Science Pulishers, Amsterdam, The Netherlands (1986).
Chater et al, In: Sixth International Symposium on Actinomycetales Biology, Akademiai Kaido, Budapest, Hungary (1986), pp. 45-54.
Chen and Okayama, "High-Efficiency Transformation of Mammalian Cells by Plasmid DNA," Molecular and Cellular Biology 7(8):2745-2752 (1987).
Chomczynski and Sacchi, "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction," Analytical Biochemistry 162:156-159 (1987).
Chu G. et al., "Electroporation for the Efficient Transfection of Mammalian Cells with DNA," Nucleic Acids Res., 15:1311-26 (1987).
Curiel et al., "Gene Transfer to Respiratory Epithelial Cells via the Receptor-mediated Endocytosis Pathway," Am J. Respir. Cell. Mol. Biol. 6:247-252 (1992).
Felgner and Ringold, "Cationic liposome-mediated transfection," Nature 337:387-388 (1989).
Felgner et al., "Lipofection: A Highly Efficient, Lipid-mediated DNA-transfection Procedure," Proc. Natl. Acad. Sci. USA 84:7413-7417 (1987).
Gaozza E et al.: "AATYK: A novel tyrosine kinase induced during growth arrest and aptosis of meyloid cells," EMBL Sequence Database, Oct. 3, 1997, Heidelberg DE.
Gerard, GF et al., (1989), FOCUS 11, 66-69.
Gilman et al., "Isolation of Sigma-28-Specific Promoters from Bacillus Subtilis DNA," Gene 32:11-20 (1984).
Glick, "Factors Affecting the Expression of Foreign Proteins in Escherichia Coli," J. Ind. Microbiol. 1:277-282 (1987).
Goding, J., "Conjugation of Antibodies with Fluorochromes: Modifications to the Standard Methods," J. Immunol. Meth. 13:215-226 (1976).
Gold, et al, "Translational Initiation in Prokaryotes," Ann. Rev. Microbiol. 35:365-404 (1981).
Gottesman, "Bacterial Regulation: Global Regulatory Networks," Ann. Rev. Genet. 18:415-441 (1984).
Gryczan, In: The Molecular Biology of the Bacilli, Acedemic Press, Inc. NY (1982).
Hamer, et al., "Regulation In Vivo of a Cloned Mammalian Gene: Cadmium Induces the Transcription of a Mouse Metallothionein Gene in SV 40 Vectors," J. Mol. Appl. Gen. 1:273-288 (1982).
Hammer et al., "Spontaneous Inflammatory Disease in Transgenic Rats Expressing HLA-B27 and Human .beta.2m: An Animal Model of HLA-B27-Associated Human Disorders," Cell 63:1099-1112 (1990).
Hanks and Hunter, "The Eukaryotic Protein Kinase Superfamily: Kinase (Catalytic) Domain Structure and Classification," FASEB Journal 9:576-595 (May 1995).
Hardie, "Roles of Protein Kinases and Phosphatases in Signal Transduction," Symp. Soc. Exp. Bio. 44:241-255 (1990).
Hida, et al., "Ectopic Expression of c-kit In Small-Cell Lung Cancer," Int. J. Can. (supp 8):108-109 (1994).
Hillier L et al.: "Human cDNA clone 265618," EMBL Sequence Database, Dec. 30, 1995, Heidelberg DE.
Hillier L et al.: "Human cDNA clone 270151," EMBL Sequence Database, Jan. 27, 1996, Heidelberg DE.
Hillier L et al.: "Human cDNA clone 308512," EMBL Sequence Database, Apr. 19, 1996, Heidelberg DE.
Hillier L et al.: "Human cDNA clone 32217," EMBL Sequence Database, Apr. 22, 1995, Heidelberg DE.
Houdebine and Chourrout, "Transgenesis in Fish," Experientia 47:891-897 (1991).
Hurby et al., "Application of Synthetic Peptides: Antisense Peptides", In Synthetic Peptides, A User's Guide, W.H. Freeman, NY, pp. 289-307 (1992).
Innis, et al., "A Guide to Methods and Applications", Academic Press, 1990.
Izaki, Jpn. J. Bacteriol. 33:729-742 (1978).
Jakoby et al., Meth. Enzym. 34:Index (1974).
Jasny, "Insect Viruses Invade Biotechnology," Science 238:1653 (1987).
John, et al., "Plasmids as Epidemiologic Markers in Nosocomial Gram-Negative Bacilli: Experience at a University and Review of Literature," Rev. Infect. Dis. 8:693-704 (1986).
Johnston and Hopper, "Isolation of the Yeast Regulatory Gene GAL4 and Analysis of its Dosage Effects on the Galactose/Melibiose Regulon," Proc. Natl. Acad. Sci. USA 79:6971-6975 (1982).
Joyner et al., "Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells," Nature 338:153-156 (1989).
Kaplan et al., "The trk Proto-Oncogene Product: A Signal Transducing Receptor for Nerve Growth Factor," Science 252:554-558 (1991).
Kasprzak et al., "Location of a Contact Site between Actin and Myosin in the Three-Dimensional Structure of the Acto-S1 Complex" Biochemistry 28:9230-8 (1989).
Kendall, et al, "Plasmid Transfer in Streptomyces Lividans: Identification of a kil-kor System Associated with the Transfer Region of pIJ101," J. Bacteriol. 169:4177-4183 (1987).
Klein, et al , "The trkB Tyrosine Protein Kinase Is a Receptor for Brain-Derived Neutrophic Factor and Neurotrophin-3," Cell 66:395-403 (1991).
Klein, et al., "Expression of the Tyrosine Kinase Receptor Gene trkB is Confined to the Murine Embryonic and Adult Nervous System," Development 109:845-850 (1990).
Klein, M. Kanehisa and C. DeLisi, "The Detection and Classification of Membrane-Spanning Proteins," Biochim. Bi
Joho Keith E.
Plowman Gregory D.
Monshipouri M.
Pronty Rebecca E.
Sugen Inc.
LandOfFree
Kinase genes and uses does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Kinase genes and uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Kinase genes and uses will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1962391