Ketorolac derivatives with considerably reduced gastro-intestina

Details Ketorolac derivatives with considerably reduced gastro-intestina Ketorolac derivatives with considerably reduced gastro-intestina

1995-06-06

1996-11-12

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20902

Patent

active

055741703

ABSTRACT:
The present invention concerns compounds of formula (I) which is the novel 2-(1-pyrrolidinyl)ethylester of (.+-.)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxyl- or ketorolac-acid, the pharmaceutically acceptable addition salts thereof, preferably oxalate. It is known that the commercially available ketorolac (trometamole salt) exhibits undesired side effects (gastrointestinal irritation and ulceration). Surprisingly, when applying the compounds according to the invention there are considerably less undesired effects which render them potentially of great advantage as analgetic/antiphlogistic agent.

REFERENCES:
Wagner et al Syn Org Chem. (1953) p. 484.

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