Ketoreductases and uses thereof

Details Ketoreductases and uses thereof Ketoreductases and uses thereof

2008-02-08

2010-10-26

Pak, Yong D (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S004000, C435S006120, C435S018000, C435S440000, C435S069100, C435S071100, C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07820421

ABSTRACT:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

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