Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2009-10-08
2010-11-16
Ramirez, Delia M (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S146000
Reexamination Certificate
active
07833767
ABSTRACT:
The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
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Davis S. Christopher
Huisman Gjalt W.
Jenne Stephane J.
Krebber Anke
Newman Lisa Marie
Codexis, Inc.
Dechert LLP
Meah MD. Younus
Ramirez Delia M
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