Ketophosphamide glycosides

Details Ketophosphamide glycosides Ketophosphamide glycosides

1990-08-20

1992-07-21

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 179, 536 172, 536 184, 536 41, C07H 1104, C07H 1300, C07H 1500

Patent

active

051324164

ABSTRACT:
Compounds of the formula (I) ##STR1## wherein R.sup.1 represents a pyranosyl radical and R.sup.4, R.sup.2, and R.sup.3 are as specified herein, compositions containing the compounds, methods of using the compounds to selectively kill tumor cells, and a process for the preparation of the compounds.

REFERENCES:
patent: 4062909 (1977-12-01), Morgan et al.
patent: 4086302 (1978-04-01), Morgan et al.
patent: 4841085 (1989-06-01), Farquhar et al.
patent: 4908356 (1990-03-01), Borch et al.
Liebigs Annalen Der Chemie, vol. 1990, No. 2, Feb. 1990, pp. 151-157, Weinheim, DE.; L. F. Tietze et al.: "Novel stable bioactivated cyclophosphamide derivatives for selective cancer chemotherapy synthesis of aldophosphamide acetal-glycosides and their glycoconjugates".
Angewandte Chemie International Edition in English, vol. 29, No. 7, Jul. 1990, pp. 782-783, Weinheim, DE.; L. F. Tietze et al.: "Development of tailor-made cytostatics activable by acid-actalyzed hydrolysis for selective tumor therapy".
Carbohydrate Research, vol. 194, Dec. 1989, pp. 155-162, Amsterdam, NL; L. F. Tietze et al.: "Stereoselective synthesis of 1,1-dialkyl-1-methoxy-methyl glucosides (acetal-glucosides)", p. 156.
Carbohydrate Research, vol. 180, 1988, pp. 253-262, Amsterdam, NL; L. F. Tietze et al.: "Stereoselective synthesis of (1-alkoxyalkyl) alpha-and beta-D-glucopyranosiduronates (acetal-glucopyranosiduronates): A new approach to specific cytostatics for the treatment of cancer", p. 253 "Abstract"; p. 255.

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