Ketone derivatives

Details Ketone derivatives Ketone derivatives

1988-09-02

1990-08-21

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 514323, 540603, 546201, 548336, A61K 31415, C07D23112

Patent

active

049506811

ABSTRACT:
The invention relates to ketones of the general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group selected from C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylC.sub.1-4 alkyl, phenyl, phenylC.sub.1-3 alkyl, --CO.sub.2 R.sup.8, --COR.sup.8, --CONR.sup.8 R.sup.9 or --SO.sub.2 R.sup.8 (wherein R.sup.8 and R.sup.9, which may be the same or different, each represents a hydrogen atom, a C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl group, or a phenyl or phenylC.sub.1-4 alkyl group, in which the phenyl group is optionally substituted by one or more C.sub.1-4 -alkyl, C.sub.1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R.sup.8 does not represent a hydrogen atom when R.sup.1 represents a group --CO.sub.2 R.sup.8 or --SO.sub.2 R.sup.8);

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patent: 4822881 (1989-04-01), Coates et al.
patent: 4859662 (1989-08-01), Coates et al.
R. Littell et al, J. Med. Chem., 1972, 15(8), 875-876 (1972).

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