Ketoalkanol esters of dihydrolysergic acid useful as 5HT recepto

Details Ketoalkanol esters of dihydrolysergic acid useful as 5HT recepto Ketoalkanol esters of dihydrolysergic acid useful as 5HT recepto

1988-05-23

1989-04-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 69, A61K 3148, C07D45704

Patent

active

048207136

ABSTRACT:
Ketoalkyl esters of 1-substituted-6-C.sub.1-4 straight chain alkyl (or allyl)ergoline-8.beta.-carboxylic acid, useful as 5HT receptor antagonists.

REFERENCES:
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patent: 3249617 (1966-05-01), Hofmann et al.
patent: 3580916 (1971-05-01), Garbrecht
patent: 4230859 (1980-10-01), Rucman
Cohen et al., J.P.E.T., 227, 327 (1983) (Cohen I).
Cohen et al., ibid, 232, 770 (1984) (Cohen II).
Lemberger et al., Life Sci., 35, 71 (1984).
Cohen et al., Drug Dev. Res., 5, 313 (1985) (Cohen IV).
Hingten et al., Abstract 37.4, Soc. for Neurosci. (13th Annual Meeting, Nov., 1983).

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