Keto amide derivatives useful as farnesyl protein transferase in

Details Keto amide derivatives useful as farnesyl protein transferase in Keto amide derivatives useful as farnesyl protein transferase in

1997-06-17

1999-07-20

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514290, 544361, 546 93, C07D40104, C07D40112, A61K 3144, A61K 31495

Patent

active

059256397

ABSTRACT:
Compounds of the following formula useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed: ##STR1## or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein:

REFERENCES:
patent: 5151423 (1992-09-01), Piwinski et al.
patent: 5684013 (1997-11-01), Afonso et al.
patent: 5696121 (1997-12-01), Bishop et al.
patent: 5714609 (1998-02-01), Doll et al.
patent: 5719148 (1998-02-01), Bishop et al.
Njoroge et al, Bioorganic & Med. Chem. Let., 6 (1996), pp. 2977-2982.
Njoroge et al, Bioorganic & Med. Chem. Let., 5 (1997), pp. 101-113.
Buss et al, Chem. and Bio., 118 (1995), pp. 787-791.
Bishop et al, J. Biol. Chem., 270 (1995), pp. 30611-30618.

Affiliated with

Also associated with

Rating

Keto amide derivatives useful as farnesyl protein transferase in does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Keto amide derivatives useful as farnesyl protein transferase in, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Keto amide derivatives useful as farnesyl protein transferase in will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1322050