Keto-aldehyde-amine addition products and method of making same

Details Keto-aldehyde-amine addition products and method of making same Keto-aldehyde-amine addition products and method of making same

1975-02-25

1978-01-03

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239A, 26029369, 26029371, 26029363, 260326A, 260326NS, 2603265FM, 2603477, 260586M, 260593R, 424244, 424267, 424274, C07D21369, C07D20744

Patent

active

040666506

ABSTRACT:
Addition products of a mono-substituted keto-aldehyde compound with a secondary amine. The compounds have the formula ##STR1## wherein R.sub.1 stands for various organic radicals as defined in the body of the specification and X is a 4-, 5- or 6-member ring or fused double ring which includes a nitrogen atom in the ring attached to the keto-aldehyde group and wherein the latter ring is substituted by =O in the two positions ortho to said nitrogen atom.
The compounds are anti-bacterial, anti-viral and anti-neoplastic agents and are valuable in connection with combatting the rejection mechanism in transplantations. They are furthermore useful as radiosensitizers in connection with radiation treatments for various purposes.

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