Ketenimine cephalosporins

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

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544 24, 544 26, 544 27, 544 28, 424246, 544 16, C07D50118

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active

042029732

ABSTRACT:
7.alpha.-Methoxy-7.beta.-acylamino cephalosporins are prepared from 7.beta.-acylamino cephalosporins through formation of a ketenimine by the action of an acid halide, formation of an addition reaction adduct of this ketenimine, treatment of the adduct with a methoxide to form a 7.alpha.-methoxy ketenimine and hydrolysis of the latter ketenimine.

REFERENCES:
patent: 3843641 (1974-10-01), Christensen et al.
patent: 3860585 (1975-01-01), Carroll et al.
patent: 3960845 (1976-06-01), Hiraka et al.
patent: 4051320 (1977-09-01), Yanagisawa et al.

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