Ketals of 3'"-dehydrocardenolide tridigitoxosides

Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugate includes potentiator; or composition comprising...

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536 61, A61K 31585, C07J 1900

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active

044367350

ABSTRACT:
The present invention provides ketals of 3'"-dehydrocardenolide tridigitoxosides of the general formula: ##STR1## in which R.sub.1 and R.sub.2 are identical alkyl radicals containing up to 3 carbon atoms or together represent a cyclic ketal containing 2 to 6 carbon atoms, R.sub.3 represents two hydrogen atoms, the group ##STR2## or the radical ##STR3## wherein R.sub.1 and R.sub.2 have the above-given meaning, and R.sub.4 is a hydrogen atom or a lower acyl or alkyl radical.
The present invention also provides processes for the preparation of these ketals, as well as pharmaceutical compositions containing them, which are useful for the treatment of cardiac insufficiency.

REFERENCES:
patent: 3907775 (1975-09-01), Losel et al.
patent: 3909357 (1975-09-01), Reinhard et al.

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