Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2006-03-21
2006-03-21
Witz, Jean C. (Department: 1651)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
Reexamination Certificate
active
07014849
ABSTRACT:
The present invention relates to the treatment of skin defects by organotypically-cultured autologous keratinocytes isolated from the outer root sheath of anagen or growing hair. Methods for primary, as well as subsequent organotypic cultures (i.e., epidermal equivalents) in fully-defined media supplemented by autologous human serum and substances isolated form blood components, with minimal allogeneic biological supplements, are disclosed herein. Techniques to prepare epidermal equivalents for transplantation by use of a biocompatible glue are also disclosed herein.
REFERENCES:
patent: 5968546 (1999-10-01), Baur et al.
patent: 6548058 (2003-04-01), Hunziker et al.
patent: 6730513 (2004-05-01), Hunziker et al.
Lenoir-Vitale et al., Archives of Dermatological Research 285(4): 197-204 (1993).
Lenoir et al., Developmental Biology 130: 610-620 (1988).
Hunziker Thomas
Limat Alain
DFB Pharmaceuticals, Inc.
Elrifi Ivor R.
Mintz, Levin, Cohn,Ferris, Glovsky and Popeo, P.C.
Stock Christina K.
Witz Jean C.
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