Chemistry: molecular biology and microbiology – Vector – per se
Patent
1993-11-01
1999-06-22
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Vector, per se
4352402, 4351723, 435 691, 536 231, 935 22, 935 6, 935 70, 935 71, C12N 1579, C12N 1510, C12N 1509
Patent
active
059142650
ABSTRACT:
A keratin K1 vector for expression of a nucleic acid sequence in an epidermal cell. The vector includes a 5' flanking region which includes necessary sequences for expression of a nucleic acid cassette, a keratin K1 3' flanking region which regulates expression of a nucleic acid sequence, predominantly in the epidermis, and a linker which connects the 5' flanking region to a nucleic acid. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. That is, the linker is not the normal gene associated with the 5' and 3' regions.
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Mehrel et al.
Greenhalgh David A.
Roop Dennis R.
Rothnagel Joseph A.
Yuspa Stuart H.
Baylor College of Medicine
Chambers Jasemine C.
Hauda Karen M.
The United States of America as represented by the Department of
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