Keratin-based hydrogel for biomedical applications and method of

Details Keratin-based hydrogel for biomedical applications and method of Keratin-based hydrogel for biomedical applications and method of

1997-11-26

1999-08-03

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 701, 424443, 424445, 525 541, 530357, A61K 3800, A61K 706, A61K 970, A61L 1500

Patent

active

059325526

ABSTRACT:
A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

REFERENCES:
patent: 4570629 (1986-02-01), Widra
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patent: 5358935 (1994-10-01), Smith et al.
patent: 5712252 (1998-01-01), Smith
patent: 5763583 (1998-06-01), Arai et al.

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