Keratin-based hydrogel for biomedical applications and method of

Details Keratin-based hydrogel for biomedical applications and method of Keratin-based hydrogel for biomedical applications and method of

1999-08-02

2000-12-12

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424400, 424422, 424443, 514 21, 514944, 530357, 530842, A61L 1500, A61F 1300, A61K 970, A61K 3800, A61K 3817

Patent

active

061594962

ABSTRACT:
A keratin hydrogel which can be used as a wound dressing and cell scaffolding. The keratin hydrogel is formed from clean, washed hair by partially oxidizing a significant percentage of disulfide linkages to form cysteic acid groups, while some disulfide linkages remain intact. The partially oxidized hair is treated with a reducing agent, thereby reducing most of the remaining disulfide linkages to cysteine-thioglycollate disulfide and cysteine groups. A soluble fraction of hair is collected and oxidized, such that the reduced sulfur groups are allowed to reform disulfide linkages, thereby binding the keratin together. The cysteic acid groups remain, providing hydrophilic sites within the hydrogel. A higher degree of partial oxidation results in a greater abundance of hydrophilic cysteic acid groups in the hydrogel.

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