Keratan sulfate oligosaccharide fraction and pharmaceutical cont

Details Keratan sulfate oligosaccharide fraction and pharmaceutical cont Keratan sulfate oligosaccharide fraction and pharmaceutical cont

1999-05-24

2000-12-12

Lee, Howard C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514 61, 514 62, 514885, A61K 3170

Patent

active

061599549

ABSTRACT:
A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at least disaccharide represented by the formula Gal(6S)-GlcNAc(6S) (in the formula, Gal, GlcN, Ac, and 6S represent a galactose, a glucosamine, an acetyl group, and a 6-O-sulfate ester, respectively) as a constitutional ingredient, and/or pharmaceutically acceptable salt thereof are used as active ingredients of anti-inflammatory agents, antiallergic agents, immunomodulators, cell differentiation inducers, and apoptosis inducers.

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Kobayashi, Masanori: Yamazaki, Fumito: Ito, Yukishiga: Ogawa, Tomoya: A Synthetic Approach to Keraten Sulfate: I. Synthesis of Trisulfated glyconteraose. Tetrahedron Letters. vol. 30, No. 34, pp. 4547-4550, 1989.
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Lust et al., "Effects of intramuscular administration of glycosaminoglycan polysulfates on signs of incipient hip dysplasia in growing pups", Am. J. Vet. Res., vol. 53(10): 1836-1843, Oct. 1992.
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