Kedarcidin antitumor chromophore and pharmaceutical composition

Details Kedarcidin antitumor chromophore and pharmaceutical composition Kedarcidin antitumor chromophore and pharmaceutical composition

1991-09-26

1992-09-01

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 28, 514 53, 536 168, 536 174, 536 181, A61K 3170, C07H 1700

Patent

active

051439069

ABSTRACT:
Kedarcidin chromophore, a non-protein chromophore isolated from kedarcidin antitumor antibiotic, is obtained from purified or partially purified kedarcidin by solvent extraction and chromatographic procedures. The chromophore is characterized and found to contain substantially all of the antitumor activity of kedarcidin.

REFERENCES:
patent: 3706729 (1972-12-01), Batcho et al.
patent: 5001112 (1991-03-01), Hofstead et al.
Otto D. Hensens et al., The Journal of Antibiotics, 1989, 42, 761-768.
H. Suzuki et al., Biochemical and Biophysical Research Communications, 1980, 94, 255-261.

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