Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1998-07-29
2000-12-12
Achutamurthy, Ponnathapu
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, A61K 3800, C07K 100
Patent
active
061600881
ABSTRACT:
The present invention relates to inhibitors of the KDEL receptor and therapeutic uses therefor. Certain proteins are functionally retained in the cellular endoplasmic reticulum via an interaction between a KDEL sequence and its receptor. According to the invention, blocking this interaction with a KDEL receptor inhibitor promotes the secretion of such proteins. In specific embodiments of the invention, KDEL receptor inhibitors may be used to promote the secretion of heat shock proteins, thereby rendering the secreted heat shock proteins more accessible to the immune system and improving the immune response to heat shock protein-associated antigens.
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Hoe Mee H.
Mayhew Mark
Rothman James E.
Achutamurthy Ponnathapu
Sloan-Kettering Institute For Cancer
Tung Peter P.
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