KCNQ5, a novel potassium channel

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S300000, C536S023100

Reexamination Certificate

active

11347493

ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5.

REFERENCES:
patent: 6649371 (2003-11-01), Jentsch
patent: 6767736 (2004-07-01), Hu et al.
patent: WO 99/07832 (1999-02-01), None
patent: WO 00/61606 (2000-10-01), None
patent: WO 00/77035 (2000-12-01), None
Cooper et al. M-channels Neuroogical diseases, neuromodulation, and drug development. Arch Neurol 60: 496-500, 2003.
Robbins et al. KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther. 90(1):1-19, 2001.
Jegla et al. Cloning and expression of human KCNQ5, a novel member of the KCNQ potassium channel family. Soc Neurosci Abs 26(1-2): 714.1, 2000.
Wickenden, AD et al. Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol. 132(2):381-384, 2001.
-& Database EMBL 'Online! Retrieved from EBI Database, Accession No. AF105202, XP002232937 Mar. 3, 2000; Kubisch et al.
-& Database EMBL 'Online! Retrieved from EBI Database, Accession No. P56696, XP002232938 Jul. 15, 1999; Kubisch et al.
Biervert, et al., “A Potassium Channel Mutation in Neonatal Human Epilepsy”;Science, 279:403-406 (Jan. 1998).
Charlier, et al., “A Pore Mutation in a Novel KQT-like Potassium Channel Gene in an Idiopathic Epilepsy Family”;Nature Genetics, 18:53-55 (Jan. 1998).
Kubisch, et al., “KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness”;Cell, 96:437-446 (Feb. 1999).
Singh, et al., “A Novel Potassium Channel Gene, KCNQ2, Is Mutated in an Inherited Epilepsy of Newborns”;Nature Genetics, 18:25-29 (Jan. 1998).
Wang, et al., “Positional Cloning of a Novel Potassium Channel Gene: KVLQT1 Mutations Cause Cardiac Arrhythmias”;Nature Genetics, 12:17-23 (Jan. 1996).
Wang, et al., “KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel”;Science, 282:1890-1893 (Dec. 1998).
Yang, et al., “Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy”;The Journal of Biological Chemistry, 273:19419-19423 (Jul. 1998).
Kananura, et al., “The New Voltage Gated Potassium Channel KCNQ5 and Neonatal Convulsions”;Genetics of Nervous System Diseases, 11:2063-2067 (Jun. 2000).
Schroder, et al., “KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain, Mediates M-type Currents”;The Journal of Biochemical Biology, 275:24089-24095 (Aug. 2000).
Lerche, et al., “Molecular Cloning and Functional Expression of KCNQ5, a Potassium Channel Subunit That May Contribute to Neuronal M-current Diversity”;The Journal of Biological Chemistry, 275:22395-22400 (Jul. 2000).
Kaufman et al., Blood 94: 3178-3184, 1999.
Wang et al., Rapid analysis of gene expression (RAGE) facilitates universal expression profiling. Nucleic Acids Res 27(23): 4609-4618, 1999.
Phillips, A., The challenge of gene therapy and DNA delivery. J Pharm Pharmacology 53:1169-1174, 2001.

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