KCNQ5, a novel potassium channel

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S252300, C435S320100, C530S350000, C536S023100, C536S023500

Reexamination Certificate

active

07049137

ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5.

REFERENCES:
patent: 6649371 (2003-11-01), Jentsch
patent: 6767736 (2004-07-01), Hu et al.
patent: WO 99/07832 (1999-02-01), None
patent: WO 00/61606 (2000-10-01), None
patent: WO 00/77035 (2000-12-01), None
patent: WO-0170759 (2001-09-01), None
patent: WO-0175108 (2001-11-01), None
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech 18(1): 34-39, 2000.
Bork, A. Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res 10: 398-400, 2000.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223, 1997.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4): 132-133, 1999.
Bork et al. Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10): 425-427, 1996.
Wells. J.A. Additivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Schroeder et al. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-tye currents. J Biol Chem 275(31): 24089-24095, 2000.
Lehmann-Horn et al. Voltage-gated ion channels and hereditary disease. Pharmacol Rev 79(4): 1317-1372, 1999.
Robbins et al. KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol Ther. 90(1)1-19, 2001.
Wickenden, AD et al. Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. Br J Pharmacol. 132(2):381-384, 2001.
Jegla et al. Cloning and expression of human KCNQ5, a novel member of the KCNQ potassium channel family. Soc Neurosci Abs 26(1-2): 714.1, 2000.
Kaufman et al. Blood 94: 3178-3184, 1999.
Wang et al. Rapid analysis of gene expression (RAGE) facilitates universal expression profiling. Nucleic Acids Res 27(23): 4609-4618, 1999.
Philips, A., The challenge of gene therapy and DNA delivery. J Pharm Pharmacology 53: 1169-1174, 2001.
Lerche, et al. “Moleuclar Cloning and Functional Expression of KCNQ5, a Potassium Channel Subunit that May contribute to Neuronal M-current Diversity”J. of Biological Chemistry(2000) vol. 275(29), pp. 22395-22400.
Kubisch et al. -& Database EMBL ′Online! Retrieved from EBI Database, Accession No. AF105202, Mar. 3, 2000.
Kubisch et al. -& Database EMBL ′Online! Retrieved from EBI Database, Accession No. P56696, Jul. 15, 1999.
Biervert, et al., “A Potassium Channel Mutation in Neonatal Human Epilepsy”;Science, 279:403-406 (Jan. 1998).
Charlier, et al., “A Pore Mutation in a Novel KQT-like Potassium Channel Gene in an Idiopathic Epilepsy Family”;Nature Genetics, 18:53-55 (Jan. 1998).
Kubisch, et al., “KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness”;Cell, 96:437-446 (Feb. 1999).
Singh, et al., “A Novel Potassium Channel Gene, KCNQ2, Is Mutated in an Inherited Epilepsy of Newborns”;Nature Genetics, 18:25-29 (Jan. 1998).
Wang, et al., “Positional Cloning of a Novel Potassium Channel Gene: KVLQT1 Mutations Cause Cardiac Arrhythmias”;Nature Genetics, 12:17-23 (Jan. 1996).
Wang, et al., “KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel”;Science, 282:1890-1893 (Dec. 1998).
Yang, et al., “Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy”;The Journal of Biological Chemistry, 273:19419-19423 (Jul. 1998).
Kananura, et al., “The New Voltage Gated Potassium Channel KCNQ5 and Neonatal Convulsions”;Genetics of Nervous System Diseases, 11-2063-2067 (Jun. 2000).

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