Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2003-06-20
2008-10-28
Chernyshev, Olga N (Department: 1649)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C530S350000, C536S023100
Reexamination Certificate
active
07442519
ABSTRACT:
The invention encompasses polypeptides and polynucleotides of three novel bipolar disorder-associated potassium channel polypeptides, KCNQ2-15bx, KCNQ2-15by and KCNQ2-15bz. The invention further relates to the use of potassium channels comprising KCNQ2 subunits for screening for modulators thereof, the use of these modulators for treating mental disorders such as bipolar disorder, schizophrenia and depression, and drugs comprising these modulators. The invention also discloses biallelic markers located in the KCNQ2 gene and their use for diagnosing mental disorders.
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SwissProt Accession No. O43526, Jul. 10, 2007.
EMBL Accession No. NM—172107, Jun. 27, 2007.
EMBL Accession No. NM—172106, Jun. 26, 2007.
EMBL Accession No. NM—004518, Jun. 26, 2007.
EMBL Accession No. NM—172108, Jun. 26, 2007.
EMBL Accession No. NM—172109, Jun. 26, 2007.
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RefseqN Accession No. NT&#x
Cavarec Laurent
Chumakov Ilya
Destenaves Benoit
Elias Isabelle
Gonthier Catherine
Chernyshev Olga N
Saliwanchik Lloyd & Saliwanchik
Serono Genetics Institute S.A.
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