Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-08-28
2007-08-28
Pak, Michael (Department: 1646)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
Reexamination Certificate
active
10131685
ABSTRACT:
The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.
REFERENCES:
patent: 6403360 (2002-06-01), Blanar et al.
patent: 9191882 (1997-07-01), None
patent: WO9921875 (1999-05-01), None
D82346Homo sapensmRNA for HNSPC, complete cds, Yokoyama et al., Sequence submitted Dec. 21, 1995; Release to public: Feb. 14, 1997; National Center for Biotechnology Information (NCBI)21.
Barhanin et al. (1996) Nature 384:78-80.
Sanguinetti et al. (1996) Nature 384:80-83.
Yang et al. (1997) Proc. Natl. Acad. Sci. 94:4017-4022.
Wang et al. (1996) Nature Genetics 12:17-23.
Wei et al. (1996) Neuropharmacology 35:805-829.
Halliwell (1990) Potassium Channels-Structure, Classification, Function and Therapeutic Potential (N.S. Cook, ed.) 384:381.
Pongs (1992) Physiol Rev. 72:S69-S88.
Biervert et al. (1998) Science 279:403-406.
Charlier et al. (1998) Nature Genetics 18:53-55.
Singh et al. (1998) Nature Genetics 18:25-29.
Jan, L.Y. and Jan. Y.N. (1992) Ann. Rev. Physiol. 54:537-555.
Catterall (1995) Ann. Rev. Biochem. 64:493-531.
U.S. Appl. No. 10/131,685, filed Apr. 24, 2002, do not print.
Yokoyama et al. (1996) DNA Research 3:311-320.
NCBI Entrez Accession No. P51787 (gi:6166005), Chouabe, et al., Jun. 15, 2004.
Database Uniprot, Oct. 1, 1966, Chouabe, et al., XP002290070.
Blanar Michael A.
Levesque Paul C.
Little Wayne A.
Neubauer Michael G.
Yang Wen-Pin
Bergen Briana C.
Bristol-Myers Squibb Co.
Handler Melissa
Pak Michael
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