Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence
Patent
1997-12-23
1999-10-12
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
4 to 5 amino acid residues in defined sequence
514 2, 514 18, C07K 500
Patent
active
059657014
ABSTRACT:
Peptides which exhibit high selectivity for the kappa opioid receptor (KOR) and long duration of peripheral action without significant entry into the brain are created which are sequences of four D-isomer amino acid residues having a C-terminus which is a mono or di-substituted amide. Representative compounds, which have an affinity for the KOR at least 1,000 times their affinity for the mu opioid receptor and an ED.sub.50 of not greater than about 0.5 mg/kg, include
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Diaz Javier Sueiras
Junien Jean Louis
Riviere Pierre J.M.
Schteingart Claudio D.
Trojnar Jerzy A.
Ferring BV
Muirheid C. Delacroix
Tsang Cecilia J.
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