Kappa receptor opioid peptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 4 to 5 amino acid residues in defined sequence

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 2, 514 18, C07K 500

Patent

active

059657014

ABSTRACT:
Peptides which exhibit high selectivity for the kappa opioid receptor (KOR) and long duration of peripheral action without significant entry into the brain are created which are sequences of four D-isomer amino acid residues having a C-terminus which is a mono or di-substituted amide. Representative compounds, which have an affinity for the KOR at least 1,000 times their affinity for the mu opioid receptor and an ED.sub.50 of not greater than about 0.5 mg/kg, include

REFERENCES:
patent: 5367053 (1994-11-01), Dooley et al.
patent: 5610271 (1997-03-01), Dooley et al.
Riviere et al., Gastroenterology,104:724-731 (1993).
Diop et al., Eur. J. Pharm., 271:65-71 (1994).
Junien and Riviere, Alimentary Pharmacology and Therapeutics, 9:117-126 (1995).
Vonvoigtlander, P.F. et al., J. Pharm. Exper. Therapeutics, 224:7-12 (1983).
G. A. Bentley et al., Br. J. Pharmac., 73:325-332 (1981).
Vanderah, T.W. et al., J. Pharm. Exper. Therapeutics, 262:190-197 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Kappa receptor opioid peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Kappa receptor opioid peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Kappa receptor opioid peptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-653834

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.