Kaposi's Syndrome Herpesvirus protease and assembly protein comp

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

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435219, 4353201, 536 232, C12N 964, C12N 950, C12N 1500, C07H 2104

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active

060338946

ABSTRACT:
Kaposi's Sarcoma Herpesvirus (KSHV) protease and assembly protein sequences are disclosed. Also disclosed are polynucleotides that encode the protease and assembly protein. The invention includes screening and detection methods, as well as KSHV protease inhibitory compositions.

REFERENCES:
Albrecht, J.C., et al., "Primary structure of the herpesvirus saimiri genome," J. Virol. 66:5047-5058 (1992).
Chang, Yuan, et al., "Identification of herpes-like DNA sequences in AIDS-associated Kaposi's sarcoma," Science 266:1865-1869 (1994).
Condra, J.H., et al., "In Vivo emergence of HIV-1 variants resistant to multiple protease inhibitors," Nature 374:569-571 (1995).
DiIanni, C.L., "Identification of the serine residue at the active site of the herpes simplex virustype 1 protease," J. Biol. Chem. 269:12672-12676 (1994).
Gao, M.L., et al., "The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth," J. Virol. 68:3702-3712 (1994).
Gibson, Wade, et al., "Identification of precursor to cytomegalovirus capsid assembly protein and evidence the processing results in loss of its carboxy-terminal end," J. Virol. 64:1241-1249 (1990).
Gibson, Wade, et al., "Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals," Perspect. Drug Discov. Desn. 2:413-426 (1994).
Liu, Fenyoung, and Bernard Roizman, "The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate," J. Virol. 65:5149-5156 (1991).
Loutsch, J.M., et al., "Cloning and sequence analysis of murine cytomegalovirus protease and capsid assembly protein genes," Biochem. Biophys. Res. Commun. 203:472-478 (1994).
Moore, P.S., et al., "Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma," J. Virol. 70:549-558 (1996).
Perona, J.J., et al., "Structural basis of substrate specificity in the serine proteases," Protein Sci. 4:337-360 (1995).
Preston, V.G., "The herpes gene simplex virus gene UL26 proteinase in the presence of the UL26.5 gene product promotes the formation of the scaffold-like structures," J. Gen. Virol. 75:2355-2366 (1994).
Preston, V.G., "Processing of the herpes simplex virus assembly protein ICP35 near its carboxy terminal end requires the product of the whole of the UL26 reading frame," Virology 186:87-98 (1992).
Russo, J.J., et al., "Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)," Proc. Natl. Acad. Sci, USA 93:14862-14867 (1996).
Unal, A., et al., "The Protease and Assembly Protein of Kaposi's sarcoma-Associated Herpes Virus (Human Herpes Virus 8), " J. of Virol. 71(9):7030-7038 (1997).
Welch, A.R., et al., "A herpesvirus maturational proteinase, assemblin: identification of its gene, putative active site domain, and cleavage site," Proc. Natl. Acad. Sci. USA 88:10792-10796 (1991).

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