Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-10-21
1992-04-21
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 723, 4352402, 435804, 530351, 530828, 530300, 53038824, 5303892, C12Q 102, C07K 1508, C07K 1700
Patent
active
051067315
ABSTRACT:
The present invention relates to a growth factor found in HTLV-II conditioned media and to compositions containing same. The growth factor of the present invention supports the growth of Kaposi's sarcoma endothelial-like cells. The factor has a molecular weight of 30K to 35K in monomeric form and a molecular weight of about 70K in dimeric form.
REFERENCES:
Delli-Bovi et al. "Processing Secretion and Biological Properties of the Fibroblast Growth Factor . . . " Molec. Cell. Biol. 8(7), 2933-2941 (Jul. 1988).
Pasquale Delli Bovi, Anna Maria Curatola, Francis G. Kern, Angela Greco, Michael Ittmann, and Claudio Basilico; "An Oncogene Isolated By Transfection Of Kaposi's Sarcoma DNA Encodes a Growth Factor That Is A Member of the FGF Family" Cell, vol. 50, 729-737 Aug. 28, 1987.
Article by Y. C. Cui, P. C. Tai, K. C. Gatter, D. Y. Mason & C. J. F. Spry; "A vascular endothelial cell antigen with restricted distribution in human foetal, adult and malignant tissues" Immunology 1983 49 183-189.
Article by Pasquale Delli-Bovi, Anna Maria Curatola, Karen M. Newman "Processing, Secretion, and Biological Properties of a Novel Growth Factor of the Fibroblast Growth Factor Family with Oncogenic Potential" Molecular and Cellular Biology, Jul. 1988, pp. 2933-2941.
Article by Eric A. Jaffe, Leon W. Hoyer, Ralph L. Nachman, entitled "Synthesis of von Willebrand Factor by Cultured Human Endothelial Cells " Proc. Nat. Acad. Sci. U.S.A. vol. 71, No. 5, pp. 1906-1909, May 1974.
Article by I. Gery, R. K. Gershon and B. H. Waksman entitled "Potentiation of Cultured Mouse Thymocyte Responses by Factors Released by Peripheral Leucocytes" The Journal of Immunology vol. 107, No. 6 pp. 118-1780.
Article by Shuji Nakamura, S. Zaki Salahuddin, Peter Biberfeld, etc. "Kaposi's Sarcoma Cells: Long-Term Culture with Growth Factor From Retrovirus-Infected CD4.sup.+ -T Cells" Science, vol. 242 pp. 426-430.
Gallo Robert C.
Nakamura Shuji
Salahuddin Syed Z.
Rosen Sam
The United States of America as represented by the Department of
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