Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-07-25
1998-11-03
Achutamurthy, Ponnathapura
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4242291, 4352351, 4353201, 530350, C07H 2104, A61K 39245, C12N 702, C07K 1403
Patent
active
058310649
ABSTRACT:
This invention provide an isolated DNA molecule which encodes interferon consensus sequence binding protein (ICSBP).
REFERENCES:
Chang et al. Science, vol. 266, No. 5192, 16 Dec. 1994, p. 1865-1869.
Bovolenta et al. (1994) Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family, Proc Natl Acad Sci USA 91, 5046-5050 (Exhibit 2).
Driggers et al. (1990) An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes, Proc Natl Acad Sci USA 87, 3743-3747 (Exhibit 3).
Kanno et al. (1983) The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 .alpha. subunit (or similar) molecule binds, Mol Cell Biol 13, 3951-3963 (Exhibit 4).
Scharf et al. (1995) Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with inter-interferon regulatory factors, J Biol Chem 270, 13063-13069 (Exhibit 5).
Thornton et al. (1996) Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by a dominant negative factor of the interferon regulatory factor family expressed in monocytic cells, Proc Natl Acad Sci USA 93, 383-387 (Exhibit 6).
Weisz et al. (1992) Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferoninducible genes, J Biol Chem 267, 25589-25596 (Exhibit 7).
Weisz et al. (1994) IFN consensus binding protein ICSBP) is a conditional repressor in IFN inductible promoters, Intl Immunol 6, 1125-1131 (Exhibit 8) and.
Yamagata et al. (1996) A novel interferon regulatory factor family transcription factor, ISSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes, Mol Cell Biol 16, 1283-1294 (Exhibit 9).
Bohenzky Roy A.
Chang Yuan
Edelman Isidore S.
Moore Patrick S.
Russo James J.
Achutamurthy Ponnathapura
Bui Phuong T.
The Trustees of Columbia University in the City of New York
White John P.
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