Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1977-09-19
1979-02-20
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424180, 536 17, C07H 1522
Patent
active
041408497
ABSTRACT:
1-N-(L-4-amino-2-hydroxybutyryl) derivatives of kanamycin C, 3'-deoxykanamycin C and 3',4'-dideoxykanamycin C have been prepared which possess high antibacterial activity against a wide variety of drug-resistant bacteria. These new derivatives are prepared by reacting L-4-amino-2-hydroxybutyric acid or a functional equivalent thereof with the 1-amino group of kanamycin C, 3'-deoxykanamycin C or 3',4'-dideoxykanamycin C.
REFERENCES:
patent: 3781268 (1973-12-01), Kawaguchi et al.
patent: 3939143 (1976-02-01), Umezawa et al.
patent: 4001208 (1977-01-01), Umezawa et al.
patent: 4029882 (1977-06-01), Wright
Fugisawa et al. "The Jour. Of Antibiotics", vol. XXVII, No. 9, 1974, pp. 677-681.
Kondo Shin-ichi
Umezawa Hamao
Brown Johnnie R.
Taylor, Jr. Herbert W.
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
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