Kallikrein-inhibiting "Kunitz Domain" proteins and analogues the

Details Kallikrein-inhibiting "Kunitz Domain" proteins and analogues the Kallikrein-inhibiting "Kunitz Domain" proteins and analogues the

1998-08-17

1999-11-30

Degen, Nancy

Chemistry: molecular biology and microbiology

Vector, per se

435 691, 4352523, 43525411, 536 231, C12N 1563, C12N 115, C12N 121, C07H 2104

Patent

active

059941251

ABSTRACT:
Proteins are disclosed that are homologous to bovine pancreatic trypsin inhibitor (BPTI) Kunitz domains, and especially proteins that are homologous to lipoprotein-associated coagulation inhibitor (LACI) Kunitz domains, which inhibit one or more plasma and/or tissue kallikreins, and uses of such proteins in therapeutic and diagnostic methods also are disclosed. In particular, Kunitz domains derived from Kunitz domains of human origin and especially to the first Kunitz domain of LACI are disclosed.

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