Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-03-10
2000-05-02
Celsa, Bennett
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 530300, 530317, 530324, 435 4, 435 74, 435 772, 435 691, A61K 3816, C07K 1400
Patent
active
060572876
ABSTRACT:
This invention relates to Kunitz domain proteins that bind to, and preferably inhibit, one or more kallikreins, and to therapeutic, diagnostic, and purification use of these proteins.
REFERENCES:
patent: 3691016 (1972-09-01), Patel
patent: 3969287 (1976-07-01), Jaworek et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4195128 (1980-03-01), Hildebrand et al.
patent: 4229537 (1980-10-01), Hodgins et al.
patent: 4247642 (1981-01-01), Hirohara et al.
patent: 4330440 (1982-05-01), Ayers et al.
patent: 4609725 (1986-09-01), Brady et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5677146 (1997-10-01), Sprecher et al.
patent: 5795865 (1998-08-01), Markland et al.
Kirchoff et al., Biol. Of Reproduction, vol. 45 pp. 350-357, 1991.
Hostomsky et al., Nucleic Acids Research, vol. 15, No. 12 pp. 4849-4856, 1987.
Adelman et al., Proteolysis of Platelet Glycoprotein Ib by Plasmin Is Facilitated by Plasmin Lysine-Binding Regions, Blood, vol. 68, No. 6, 1280-1284, (Dec. 1986).
Albrecht et al., Kunitz-Type Proteinase Inhibitors Derived by Limited Proteolysis of the Inter-.alpha.-Trypsin Inhibitors From Several Mammalian Sera, Hoppe-Seyler's Z. Physiol. Chem., vol. 364, 1697-1702, (Dec. 1983).
Albrecht et al., Elastase Inhibition by the Inter-.alpha.-Trypsin Inhibitor and Derived Inhibitors of Man and Cattle, Hoppe-Seyler's Z. Physiol. Chem., vol. 364, 1703-1708, (Dec. 1983).
Anba et al., Improving the Stability of a Foreign Protein in the Periplasmic Space of Escherichia coli, Biochemie, vol. 70(6), 727-722 (1988).
Angliker et al., The Synthesis of Lysylfluoromethanes and their Properties as Inhibitors of Trypsin, Plasmin and Cathepsin B, Biochem, vol. 241, (3) 871-875, (Jan. 1987).
Atherton et al., Peptide Synthesis. Part 2.sup.1 Procedures for Solid-phase Synthesis using N.sup..alpha. -Fluorenylmethoxycarbonylamino-acids on Polyamide Supports. Synthesis of Substance P and of Acyl Carrier Protein 65-74 Decapeptide, J Chem Soc Perkin Trans, vol. 1, 538-546, (1981).
Auerswald et al., Expression, Isolation and characterization of Recombinant [Arg.sup.15, Glu.sup.52 ] Aprotinin, Biol Chem Hoppe-Seyler, vol. 369 (supplement), 27-35, (May 1988).
Balduyck et al., Human Urinary Proteinase Inhibitor: Inhibitory Properties and Interaction with Bovine Trypsin, Biol Chem Hoppe-Seyler, vol. 366, 9-14, (Jan. 1985).
Baneyx and Georgiou, In Vivo Degradation of Secreted Fusion Proteins by the Escherichia coli Outer Membrane Protease OmpT, J Bacteriol, vol. 172, No. 1, 491-494, (Jan. 1990).
Baneyx and Georgiou, Construction and Characterization of Escherichia coli Strains Deficient in Multiple Secreted Proteases: Protease III Degrades High-Molecular-Weight Substrates In Vivo, J Bacteriol, vol. 173, No. 8, 2696-2703, (Apr. 1991).
Berndt et al., Designed Replacement of an Internal Hydration Water Molecule in BPTI: Structural and Functional Implications of a Glycine-to-Serine Mutation, Biochemistry, vol. 32, 4564-4570, (1993).
Bhoola et al., Bioregulation of Kinins: Kallikreins, Kininogens, and Kininases, Pharmocological Reviews, vol. 44, No. 1, 1-80, (1992).
Browne et al., Expression of recombinant human plasminogen and aglycoplasminogen in HeLa cells, Genebank, Entry M74220.
Broze et al., Regulation of Coagulation by a Multivalent Kunitz-Type Inhibitor, Biochem, vol. 29, n. 33, 7539-7546, (Aug. 21, 1990).
Currie et al., Design and Synthesis of a Bicyclic Non-Peptide .beta.-Bend Mimetic of Enkephalin, vol. 49, No. 17, 3489-3500, (1993).
Dennis & Lazarus, Kunitz Domain Inhibitors of Tissue Factor-Factor VIIa (I), J Biological Chem, vol. 269, No. 35, 22129-22136, (1994).
Dennis & Lazarus, Kunitz Domain Inhibitors of Tissue Factor-Factor VIIa (II), J Biological Chem, vol. 269, No. 35, 22137-22144, (1994).
Diaz et al., The Design of Water Soluble .beta.-Sheet Structure Based On a Nucleation Strategy, Tetrahedron, vol. 49, No. 17, 3533-3545, (1993).
Dimaio et al., A New Class of Potent Thrombin Inhibitors That Incorporates a Scissile Pseudopeptide Bond, Federation of European Biochemical Societies, vol. 282, No. 1, 47-52, (Apr. 1991).
Eigenbrot et al., Structural Effects Induced by Removal of a Disulfide-bridge: the X-ray Structure of the C30A/C51A Mutant of Basic Pancreratic Trypsin Inhibitor at 1.6 A, vol. 3, No. 7, 591-598.
Ellis et al., The Urokinase Receptor: Involvement in Cell Surface Proteolysis and Cancer Invasion, Ann NY Acad Sci, vol. 667, 13-31, (1992).
Fidler & Ellis, The Implications of Angiogenesis for the Biology and Therapy of Cancer Metastasis, Cell, vol. 79, 185-188, (Oct. 21, 1994).
Fields, G.B., Solid Phase Peptide Synthesis Utilizing 9-fluorenylmethoxycarbonyl Amino Acids, Int J Polypeptide Prot Res, vol. 35, 161-214, (1990).
Fraedrich et al., Reduction of Blood Transfusion Requirement in Open Heart Surgery By Administration of High Doses of Aprotinin--Preliminary Results, Thorac Cardiovasc Surgeon, vol. 37, No. 2, 89-91, (1989).
Freidinger, et al., Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides, J. Org. Chem., vol. 47, pp. 104-109, 1982.
Gardell, et al., The Search for the Ideal Thrombolytic Agent: Maximize the Benefit and Minimize the Risk, Toxicologic Pathology, vol. 21, No. 2, pp. 190-198, 1993.
Girard, et al., Functional Significance of the Kunizt-type Inhibitory Domains of Lipoprotein-Associated Coagulation Inhibitor, Nature, vol. 338, pp. 518-520, Apr. 6, 1989.
Girard, et al., Structure of the Human Lipoprotein-associated Coagulation Inhibitor Gene, The Journal of Biological Chemistry, vol. 266, No. 8, pp. 5036-5041, Mar. 15, 1991.
Hoover, et al., Amino Acids of the Recombinant Kringle 1 Domain of Human Plasminogen that Stabilize Its Interaction with w-Amino Acids, Biochemistry, vol. 32, pp. 10936-10943, 1993.
Hortin, et al., Allosteric Changes in Thrombin's Activity Produced by Peptides Corresponding to Segments of Natural Inhibitors and Substrates, The Journal of Biological Chemistry, vol. 266, No. 11, pp. 6866-6871, Apr. 15, 1991.
Hynes, et al., X-ray Crystal Structure of the Protease Inhibitor Domain of Alzheimer's Amyloid .beta.-Protein Precursor, Biochemistry, vol. 29, pp. 10018-10022, 1990.
Kemp, et al., Synthesis of Peptide-Functionalized Diacylaminoepinodolidiones as Templates for .beta.-Sheet Formation, Tetrahedron Letters, vol. 29, No. 40, pp. 5077-5080, 1988.
Kido, et al., Kunitz-Type Protease Inhibitor Found in Rat Mast Cells, The Journal of Biological Chemistry, vol. 263, No. 34, pp. 18104-18107, Dec. 5, 1988.
Kido, et al., Protease-Specificity of Kunitz Inhibitor Domain of Alzheimer's Disease Amyloid Protein Precursor, Biochemical and Biophysical Research Communications, vol. 167, No. 2, pp. 716-721, Mar. 16, 1990.
Kline, et al., Hirulog Peptides with Scissile Bond Replacements Resistant to Thrombin Cleavage, Biochemical and Biophysical Research Communications, vol. 177, No. 3, pp. 1049-1055, Jun. 28, 1991.
Laskowski, et al., Protein Inhibitors of Proteinases, Ann. Rev. Biochem. vol. 49, pp. 593-626, 1980.
Leatherbarrow, et al., Design of a Small Peptide-Based Proteinase Inhibitor by Modeling the Active-Site Region of Barley Chymotrypsin Inhibitor 2, Biochemistry, vol. 30, pp. 10717-10721, 1991.
Lohmann, et al., Plasmin- and Plasminogen-Activator Inhibitors after Excimer Laser Photorefractive Keratectomy: New Concept in Prevention of Postoperative Myopic Regression and Haze, Refractive & Corneal Surgery, vol. 9, pp. 300-302, Jul./Aug. 1993.
Lucas, et al., The Binding of Human Plasminogen to Fibrin and Fibrinogen, The Journal of Biological Chemistry, vol. 258, No. 7, pp. 4249-4256, Apr. 10, 1983.
McConnell, et al., New Leupeptin Analogues: Synthesis and Inhibition Data, J. Med. Chem., vol. 33, pp. 86-93, 1990.
Merrifield, R.B., Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide, J. Amer. Chem. Soc., vol. 85, pp. 2149-2154, Jul. 20, 1993.
Merrifield, Bruce, Solid Phase Synthesis, Science, vol. 232, pp. 341-347, Apr. 18, 1986.
Miyajima, et al., Secretion of Mature Mouse Interleukin-2 by Saccharomyces Cerevisiae: Use of a General Secretion Vector Containing Promoter and Leader Sequences of the Mating Pheromon
Ladner Robert Charles
Markland William
Celsa Bennett
Dyax Corp.
Yankwich Leon R.
Zwicker Kenneth P.
LandOfFree
Kallikrein-binding "Kunitz domain" proteins and analogues thereo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Kallikrein-binding "Kunitz domain" proteins and analogues thereo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Kallikrein-binding "Kunitz domain" proteins and analogues thereo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1593844