Kainate-binding, human CNS receptors of the EAA3 family

Details Kainate-binding, human CNS receptors of the EAA3 family Kainate-binding, human CNS receptors of the EAA3 family

1995-06-07

2000-01-25

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530300, 530395, 4241851, 536 235, C07K 14705

Patent

active

060180234

ABSTRACT:
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

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