Kainate-binding human CNS receptors of the EAA2 family

Details Kainate-binding human CNS receptors of the EAA2 family Kainate-binding human CNS receptors of the EAA2 family

1994-02-28

1997-03-25

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 4353201, 435348, 435354, 435356, 435357, 435361, 435364, 435365, 435367, 435369, 536 235, 536 2431, C12N 121, C12N 510, C12N 1512, C12N 1579

Patent

active

056144067

ABSTRACT:
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors, of the kainate binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

REFERENCES:
Hollmann et al, Nature (1989) 342:643.
Keinanen et al, Science (1990) 249:556.
Boulter et al, Science (1990) 249:1033.
Bettler et al, Neuron (1990) 5:583.
Sommer et al, Science (1990) 249:1580.
Monyer et al, Neuron (1991) 6:799.
Nakanishi et al, Neuron (1990) 5:569.
Hollmann et al, Science (1991) 252:851.
Verdoorn et al, Science (1991) 252:1715.
Egebjerg et al, Nature (1991) 351:745.
Wada et al, Nature (1991) 342:684.
Gregor et al, Nature (1989) 342:689.
Werner et al, Nature (1991) 351:742.
Barnett et al, Nucleic Acids Res. (1990) 18(10):3094.
William Sun, et al., "Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors"; Proc. Natl. Acad. Sci. USA, vol. 89, pp. 1443-1447, Feb. 1992.
Carmie Puckett, et al., "Molecular cloning and chromosomal localization of one of the human glutamate receptor genes"; Proc. Natl. Acad. Sci. USA, vol. 88, pp. 7557-7561, Sep. 1991.
Lee, C.C. et al. Science 239:1288-1291 (1988).
Suggs, S.V. et al. PNAS 78(11):6613-6617 (1981).

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