Kainate-binding, human CNS receptors of the EAA2 family

Details Kainate-binding, human CNS receptors of the EAA2 family Kainate-binding, human CNS receptors of the EAA2 family

1993-07-15

1996-02-27

Furman, Keith C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 691, 4352402, 436501, 530350, C12N 510, C12N 1510, C12Q 100, G01N 3350

Patent

active

054947928

ABSTRACT:
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors, of the kainate binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commerical significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

REFERENCES:
Egebjerg, J. et al. Nature 351:745-749 (1991).
Wada, K. et al. Nature 342:684-689 (1989).
Werner, P. et al. Nature 351:742-744 (1991).
Bochet, P. et al. in Comparative Molecular Neurobiology, ed. by Y. Pideon, pp. 224-231. (1993).
Bowie, D. et al., British Journal of Pharmacology 111(3):803-810 (1994).

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