Kainate-binding, human CNS receptors of the EAA2 family

Details Kainate-binding, human CNS receptors of the EAA2 family Kainate-binding, human CNS receptors of the EAA2 family

1997-03-20

1999-11-09

Jacobson, Dian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530839, 514 2, 514 12, C07K 14435, C07K 14705, A61K 3817

Patent

active

059817046

ABSTRACT:
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors, of the kainate binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor simulation.

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