Kainate-binding human CNS receptors of the EAA1 family

Details Kainate-binding human CNS receptors of the EAA1 family Kainate-binding human CNS receptors of the EAA1 family

1995-04-03

1997-04-01

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4353171, 436501, 530350, 536 235, C07K 14705, C12N 510, C12N 1509, C12N 1512

Patent

active

056164815

ABSTRACT:
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors, of the kainate binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

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