Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, D

Details Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, D Kainate-binding human CNS glutamate receptors EAA3C and EAA3D, D

1995-03-15

1996-08-20

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 4352402, 4352523, 43525411, 4353171, 536 235, 530350, 530395, C12N 1512, C12N 510, C07K 14705, C08L 8900

Patent

active

055478557

ABSTRACT:
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Disclosed is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

REFERENCES:
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