K-252a derivatives for treatment of neurological disorders

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

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514211, C07D49822, A61K 3155

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056211007

ABSTRACT:
The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.

REFERENCES:
patent: 4554402 (1985-11-01), Hawkins et al.
patent: 4735939 (1988-04-01), McCoy et al.
patent: 4816450 (1989-03-01), Bell et al.
patent: 4877776 (1989-10-01), Murakata et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5093330 (1992-03-01), Caravatti et al.
Tadashi et al; Chem Abs., 111: 77750n 1989.
Kn usel et al; J. Neurochem., vol. 57 No. 3; pp. 955-962, 1991.
Chu-Wang et al., J. Comp. Neur, 177:33-58.
Oppenheim, R., Journal of Comparative Neurology, 246:281-286, 1986.
Hamburger, V., J. Comp. Neur, 160:535-546, 1975.
Akiyama et al., Chemical Abstracts, Col. 107, Issued 1987, Abstract No. 197943 (Jun. 1, 1987).
Bozyczko-Coyne, D., Journal of Neuroscience Methods, 50:205-216, 1993.
Chiu, A. et al., Journal of Comparative Neurology, 328:328-363, 1993.
Dunnett, S. et al., TINS, 14:494-501, 1991.
Fibiger, H., TINS, 14:220-223, 1991.
Glicksman, M. et al., Journal of Neurochemistry, 61:210-221, 1993.
Glicksman, M., "K-255a Molecules as Promoters . . . ", Third Int. Conference on Nerve Growth Factor (NGF) and related molecule, Chateau Lake Louise, Alberta, Apr. 26--May 1, 1994.
Glicksman, M. et al., Society of Neuroscience Abstracts, 19:680, 1993.
McManamann, J. et al., Neuron, 4:891-898, 1990.
Olton, D. et al., "Dementia: Animal Models . . . " Psychopharmacology: The Third Generation of Progress, Raven Press, NY, 1987.
Oppenheim, R. et al., Journal of Comparative Neurology, 210:174-189, 1982.
Smith, G., Brain Research Reviews, 13:103-118, 1988.
Wenk, G. et al., Exp. Brain Research, 56:335-340, 1984.
Oppenheim, R. et al., Science, 240:919-921, 1988.
Nakadate et al., Biochemical Pharmacology 37:1541-1545, 1988.
Nakanishi et al., The Journal of Antibiotics 39:1066-1071, 1986.
Sako et al., Cancer Research 48:4646-4650, 1988.
Shepherd, "The Synaptic Organization of the Brain" Second Edition, pp. 308-314 (Oxford University Press, New York, 1979).
Siman et al., Neuron 1:279-287, 1988.
Smith et al., Biochem. and Biophys. Research Communications 152:1497-1503, 1988.
Steglich et al., Angew. Chem. Int. Ed. Engl. 19:459-460, 1980.
Tischler et al., The Journal of Biological Chemistry 266:1141-1146, 1991.
Vitullo, Press Release "Cephalon and Kyowa Hakko Co., Ltd. Announce Collaboration," Jun. 2, 1992.
Wolf et al., Biochem. and Biophys. Research Communications 154:1273-1279, 1988.
Nakanishi et al., J. of Anthibiotics, vol. 32, No. 8, Issued Aug. 1986, pp. 1066-1071.
Hirata, Chemical Abstracts, vol. 107, Issued 1987, Jul. 10, 1987, Abstract No. 23675oy.
Hirata et al., Chemical Abstracts, vol. 107, Issued 1987, Abstract No. 236751Z, Jul. 10, 1987.
Hirata et al., Chemical Abstracts, vol. 111, Issued 1989, Abstract No. 194456g, Dec. 1, 1988.
Davis et al., J. Med. Chem. 35:177-184, 1992.
Davis et al., FEBS Letters 259:61-63, 1989.
Hara et al., Journal of Cerebral Blood Flow and Metabolism 10:646-653, 1990.
Hashimoto, The Journal of Cell Biology 107:1531-1539, 1988.
Kase et al., The Journal of Antibiotics 39:1059-6219, 1986.
Kiyoto et al., Biochem. and Biophys. Research Communications 148:740-746, 1987.
Kn usel et al., Journal of Neurochemistry 59:715-722, 1992.
Koizumi et al., The Journal of Neuroscience 8:715-721, 1988.
Lazarovici et al., Journal of Neuroscience Research 23:1-8, 1989.
Matsuda et al., Biochem. J. 256:75-80, 1988.
Moody et al., J. Org. Chem. 57:2105-2114, 1992.
Nabeshima et al., The Journal of Pharmacology and Experimental Therapeutics 257:562-566, Issued Jan. 2, 1991.
Abe et al., Annals of the New York Academy of Sciences 559:259-268, Issued Jul. 5, 1989.
Borasio, Neuroscience Letters 108:207-212, Issued Jan. 1, 1990.

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