Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-09-16
1996-05-14
Haley, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514410, A61K 3140
Patent
active
055167721
ABSTRACT:
Disclosed are derivatives of the indolocarbazole alkaloid K-252a of the Formulae I-VI, useful for enhancing neurotrophin-induced activity of neurotrophin responsive cells. A particularly preferred neurotrophin is NT-3, and a particularly preferred neurotrophin responsive cell is one which comprises a trk receptor. The enhanced neurotrophin-induced activity occasioned by the disclosed K-252a derivatives may be determined by the following assays: ChAT activity; DRG neuronal survival; or cell division (mitogenesis).
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Glicksman Marcie A.
Hudkins Robert L.
Murakata Chikara
Neff Nicola T.
Rotella David P.
Burgoon, Jr. Richard P.
Cephalon Inc.
Haley Jacqueline
Kyowa Hakko Kogyo Co. Ltd.
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