K-252 compounds

Details K-252 compounds K-252 compounds

1988-12-22

1989-10-31

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

540472, 424122, 435164, 536 24, A61K 3171, C12P 1938, C07H 1904

Patent

active

048777765

ABSTRACT:
A K-252 compound represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently H or OH; X represents COOH, COOR or CH.sub.2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl has C-kinase inhibitory activity and is expected to be useful as an active ingredient of anti-tumor agents, etc.

REFERENCES:
patent: 4555402 (1984-09-01), Matsuda et al.
J. Antibiotics, 30(4), 275-282 (1977), Omura et al., "A New Alkaloid AM-2282 of Streptomyces Origin . . . ".
J.C.S. Chem Comm, 800-801 (1978) Furasaki, et al., "X-Ray Crystal Structure of Staurosporine . . . ".
J. Antibiotics 38(10), 1437-1439, (1985), Sezaki, et al., "A New Antibiotic SF-2370 . . . ".

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