Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1999-11-22
2000-10-24
Page, Thurman K
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424422, 424436, 424486, 424488, 424499, 514492, A61F 1300
Patent
active
061363367
ABSTRACT:
Novel suppository pharmaceutical formulations of the platinum antitumor agent, JM216, are provided. Such dosage forms provide an alternative to the oral form currently available and offer improved bioavailability of this promising drug.
REFERENCES:
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Brunner et al. Synthesis and antitumor activity of platinum (II) complexes of benzyl-1,2-diaminoethane ligands. Chem. Ber. 123 (5), 1029-38, 1990.
Lin et al. Grinding effect on some pharmaceutical properties of drugs by adding beta-cyclodextrin. drug. Dev. Ind. Pharm > 14(1), 99-118.
McKeage et al. Cancer. Chemother. Pharmac. vol.36, 451-458, 1995.
Kuwahara Etsuhisa
Takahashi Norimitsu
Tanaka Makoto
Bristol--Myers Squibb Company
Channavajjala Lakshmi
Morse David M.
Page Thurman K
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