Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition
Patent
1996-05-17
1999-09-28
Ludlow, Jan
Chemical apparatus and process disinfecting, deodorizing, preser
Control element responsive to a sensed operating condition
347 68, 422 65, G01N 302
Patent
active
059583428
ABSTRACT:
Devices and methods are provided for precise production of arrays of microspots. A pulse jetting device is employed having a capillary of micron dimensions, with a portion of the capillary proximal to the jetting orifice circumferentially surrounded by a piezoelectric transducer. By appropriate design of the capillary, orifice and piezoelectric transducer, droplets can be formed on a surface, separated by as little as 80 microns center-to-center, and having at least about a 15 micron spacing at the border. The subject substrate arrays can be used for providing miniaturized arrays of reagents, such as nucleic acids, for detecting the presence of homologous sequences in a sample.
REFERENCES:
patent: 4367482 (1983-01-01), Heinzl
patent: 4374388 (1983-02-01), Heinzl
patent: 4375066 (1983-02-01), Herd
patent: 4376284 (1983-03-01), Bader et al.
patent: 4412232 (1983-10-01), Weber et al.
patent: 4414552 (1983-11-01), Bergmann et al.
patent: 4562157 (1985-12-01), Lowe et al.
patent: 4866166 (1989-09-01), Wigler
patent: 4877745 (1989-10-01), Hayes et al.
patent: 5053100 (1991-10-01), Hayes
patent: 5073495 (1991-12-01), Anderson
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5202223 (1993-04-01), Drmanac et al.
patent: 5202418 (1993-04-01), Lebl et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5338688 (1994-08-01), Deeg et al.
patent: 5338831 (1994-08-01), Lebl et al.
patent: 5342585 (1994-08-01), Lebl et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5391667 (1995-02-01), Dellinger
patent: 5403708 (1995-04-01), Brennan et al.
patent: 5412087 (1995-05-01), McGall et al.
Southern, "Detection of Specific Sequences Among DNA Fragments Separated by Gel Electrophoresis," J. Mol. Biol. (1975), 98:503-517.
Maskos and Southern, "Oligonucleotide Hybridisations on Glass Supports: A Novel Linker for Oligonucleotide Synthesis and Hybridisation Properties of Oligonucleotides Synthesised in situ," Nucleic Acid Research (1992), 20:1679-1684.
Southern et al., "Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides: Evaluation Using Experimental Models," Genomics (1992), 13:1008-1017.
Human Genome 1991-92 Program Report (Jun. 1992), U.S. Department of Energy, Office of Energy Research, Office of Health and Environmental Research, Washington, D.C.
Lipshutz, "Likelihood DNA Sequencing By Hybridization," J. of Biomolecular Structure & Dynamics (1993), 11:637-653.
Schena, M., "Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray", Science (Oct. 1995), 270:467-470.
Baldeschwieler John
Gamble Ronald C.
Theriault Thomas P.
Incyte Pharmaceuticals Inc.
Ludlow Jan
LandOfFree
Jet droplet device does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Jet droplet device, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Jet droplet device will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-699790