Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1998-06-23
1999-08-03
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424451, 424464, A61K 600, A61K 700, A61K 920, A61K 948
Patent
active
059322357
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a jellied medical composition for oral administration, specifically to a jellied medical composition for oral administration which is easily taken by patients of advanced age or patients with dysphagia, more specifically to a jellied medical composition for oral administration which does not easily cause syneresis and retains preservation stability at the medical level in terms of maintenance of appearance and pH of the composition and maintenance of dispersibility and the contents of the effective components in the composition, and further to a jellied medical composition for oral administration packed in a disposable container a predetermined dose of which can be taken with solidity appropriate for swallowing and with good texture, which is suitable for improvement of compliance.
BACKGROUND ART
In future medicine, it is indispensable to solve medical problems in the aged society. One of the problems of such medicine for the aged is great difficulty for patients with advanced age in taking any of the currently used dosage forms of medical compositions for oral administration. Patients with dysphagia have also been suffering from this problem that it is difficult to take a medical composition for oral administration.
For example, the medical compositions for oral administration listed in the general medical preparations of Japanese Pharmacopoeia include tablets, capsules, pills, powders, liquid, syrup, and the like. Such dosage forms are not easily taken by patients of advanced age, particularly patients with dysphagia. Among these, liquid and syrup preparations are easily taken by them as compared with the other dosage forms. However, because of liquid, there are problems to be overcome, when formulating into dosage forms, such as masking of bitterness of effective components, their dispersibility and stability. Particularly, patients with dysphagia cannot take such a medical composition because they are choked by water. Ito et al. (Monthly Pharmaceutical, Vol. 37, No. 11, p 45-49 (1995)) reported that patients with advanced age cannot easily take tablets or capsules depending on their sizes. Thus, it has been desired to develop new pharmaceutical preparations that are easily taken by patients of advanced age or patients with dysphagia.
In order to solve the above problems for patients of advanced age, Ito et al. proposed to use liquid preparations having high viscosity as one of the medical preparations for them (Monthly Pharmaceutical, Vol. 37, No. 11, p 45-49 (1995)). Another report (Clinical Nutrition, Vol. 79, No. 1, p 22-39 (1991)) describes that liquid preparations having high viscosity are favorably used as one of the dosage forms of medical preparations that can be easily taken by patients with dysphagia. Thus, from general viewpoints, it has been considered that liquid preparations having high viscosity are appropriate as a dosage form of medical preparations for oral administration that can be easily taken by patients of advanced age and patients with dysphagia.
Actually for clinical use for, it was reported that, as nosocomial medicines, a highly viscous liquid pharmaceutical preparation was prepared usually using one or two or more of gelatin, pectin, xanthan gum, carrageenan, and the like upon use or with the short applicable term to administer it to patients who could not easily take usually used medical preparations for oral administration (Medical Care and New Drugs, Vol. 13, No. 11, p 208-214 (1994), Pharmacy, Vol. 42, No. 11, p 53-59 (1991)). However, even the above-described highly viscous liquid pharmaceutical preparations are still unsatisfactory in easiness to take. Further, these preparations are used only for a limited period of short time since it is difficult to secure their long-term stability. In other words, there are such problems that the viscous pharmaceutical preparations cannot keep viscosity to become an aqueous state, that their original appearances are difficult to maintain, and that their preservation stability inc
REFERENCES:
patent: 5648093 (1997-07-01), Gole et al.
Dairaku Masatake
Komagata Takeshi
Misawa Masayo
Ninomiya Hiroshi
Shimizu Toshio
Howard Sharon
OHTA Pharmaceutical Co., Ltd.
Page Thurman K.
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