Janus family kinases and identification of immune modulators

Details Janus family kinases and identification of immune modulators Janus family kinases and identification of immune modulators

2005-08-01

2009-02-10

Schwadron, Ron (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S388260, C530S388750, C530S389100, C530S388730

Reexamination Certificate

active

07488808

ABSTRACT:
An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.

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