Jak kinases and regulation of cytokine signal transduction

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S320100, C435S455000, C435S325000

Reexamination Certificate



The invention relates generally to the Jak family of kinases. This includes the DNA and amino acid sequences for Jak 3 kinases. Additionally, the invention concerns expression vectors comprising DNA sequences encoding a Jak 3 kinase and host cell containing such expression vectors.

patent: 5190931 (1993-03-01), Inouye
patent: 5658791 (1997-08-01), Wilkes et al.
patent: 5705625 (1998-01-01), Civin et al.
patent: 5914393 (1999-06-01), Coleman et al.
patent: 6136595 (2000-10-01), Ihle et al.
patent: 6210654 (2001-04-01), Ihle et al.
patent: WO 92/10519 (1992-06-01), None
patent: WO 93/15201 (1993-08-01), None
Fuortes, M. Accession No. U08340. Apr. 21, 1994.
Kennell, D.E. Principles and Practices of Nucleic acid hybridization. Progr. Nucl. Acid Res. Mol. Biol. 11:259-301, 1971.
Littman et al. Nature 326:85-88, 1987.
Firmbach-Kraft et. al., tyk2, prototype of a novel class of non-receptor tyrosine kinase genes; 1990, Oncogene 5: 1329-1336.
Takahashi et. al.; Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases; 1994, FEBS Letters 342:124-128.
Kawamura et. al.; Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes; 1994, Proc. Natl. Acad. Sci. vol. 91: 6374-6378.
Harper et. al.; JAK2, a third member of the JAK family of protein tyrosine kinases, 1992, Oncogene 7: 1347-1353.
Wilks et. al., Two Novel Protein-Tyrosine Kinases, Each with a Second Phosphotransferase-Related Catalytic Domain, Define a New Class of Protein Kinase, 1991; Molecular and Cellular Biology: 2057-2065.
Rane et. al.; JAK3; A novel JAK kinase associated with terminal differentiation of hematopoietic cells, 1994, Oncogene 9: 2415-2423.
Ngo et.al.; Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox; 1994, The Protein Folding Problem and Tertiary Structure Prediction: 491-495.
Rudinger, Characteristics of the amino acids as components of a peptide hormone sequence, 1976; Peptide Hormones:1-7.
Argotsinger, L.S. et al., “Identification of JAK2 as a Growth Hormone Receptor-Associated Tyrosine Kinase,”Cell 74:237-244, Cell Press (Jul. 1993).
Bartholomew, C. and J.N. Ihle, “Retroviral Insertions 90-Kilebases Proximal to the Evi-1 Mycloid Transforming Gene Activate Transcription from the Normal Promoter,”Mol. Cell. Biol. 11(4): 1820-1828, American Society for Microbiology (1991).
Bird, T.A. et al., “Evidence that NAP (Nitrogen-Activated Protein) Kinase Activation May Be a Necessary but not Sufficient Signal for a Restricted Subset of Responses in IL-1 Treated Epidermoid Cells,”Cytokine 4(6):429-440, International Cytokine Society, Academic Press Ltd, (Nov. 1992).
Campbell, G.S. et al., “Evidence for Involvement of the Growth Hormone Receptor-associated Tyrosine Kinase in Actions of Growth Hormone,”J. Biol. Chem. 268(10):7427-7434, The American Society for Biochemistry and Molecular Biology, Inc. (Apr. 1993).
Carroll, M.P. et al., “Erythropoietin Induces Raf-1 Activation and Raf-1 is Required for Erythropoietin-mediated Proliferation,”J. Biol. Chem. 266(23):14964-14969, The American Society for Biochemistry and Molecular Biology, Inc. (1991).
Carroll, M.P. et al., “Interleukin-3 and Granulocyte-Macrophage Colony-stimulating Factor Mediate Rapid Phosphorylation and Activation of Cytosolic o-raf,”J. Biol. Chem. 265(32):19812-19817, The American Society for Biochemistry and Molecular Biology, Inc. (1990).
Cleveland, J.L. et al., “Tyrosine Kinase Oncogenes Abrogate Interleukin-3 Dependence of Murine Myeloid Cells through Signaling Pathways Involving c-myc: Conditional Regulation of c-myca Transcription by Temperature-Sensitive, v-abl,”Mol. Cell. Biol. 9(12):5685-5695, American Society (1989).
Duaanter-Fourt, I. et al., “Erythropoietin Induces the Tyrosine Phosphorylation of Its Own Receptor in Human Erythropoietin-responsive Cells,”J. Biol. Chem. 267(15):10670-10675, The American Society for Biochemistry and Molecular Biology, Inc. (May 1992).
Edgington, S.M., “Molecular Crosstalk: Will virology and growth-factor research aid cytokine drug discovery”Bio/Technol. 11:465-468, Nature Publishing Co. (Apr. 1993).
Firmbach-Kraft, I. et al., “tyk2, Prototype of a novel class of non-receptor tyrosine kinase genes,”Oncogene 5:1329-1336, Macmillan Press Ltd. (1990).
Fu, X.-Y., “A Transcription Factor with SH2 and SH3 Domains is Directly Activated by an Interferon α-induced Cytoplasmic Protein Tyrosine Kinase(s),”Cell 70:323-335, Cell Press (Jul. 1992).
Fu, X.-Y. et al., “The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction,”Proc. Natl. Acad. Sci. USA 89:7840-7843, National Academy of Sciences of the USA (Aug. 1992).
Fung, M.R. et al., “A Tyrosine Kinase Physically Associates With the β-Subunit of the Human IL-2 Receptor,”J. Immunol. 147(4):1253-1260, The American Association of Immunologists (1991).
Gilmour, K.C. and N. C. Reich, “Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors,”Proc. Natl. Acad. Sci. USA 91:6850-6854, National Academy of Science of the USA (Jul. 1994).
Goodman, P.A. et al., “Role of Tyrosine Kinases in Induction of the c-jun Proto-oncogene in Irradiated B-lineage Lymphoid Cells,”J. Biol. Chem. 273:17742-17748, The American Society for Biochemistry and Molecular Biology, Inc. (Jul. 1998).
Hanks, S.K. et al., “The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains,”Science 241:42-52, Association for the Advancement of Science (1988).
Harpur, A.S. et al., “JAK2, a third member of the JAK family of protein tyrosine kinases,”Oncogene 7:1347-1353, Macmillan Press Ltd. (Jul. 1992).
Howard, O.M.Z. et al., “Characterization of a class 3 tyrosine kinase,”Oncogene 7:895-900, Macmillan Press Ltd. (May 1992).
Hunter, T., “A Thousand and One Protein Kinases,”Cell 50:823-829, Cell Press (1987).
Hunter, T., “Cytokine Connections,”Nature 366:114-116, Macmillan Publishers Ltd. (Nov. 1993).
Ihle, J.N., “Interleukin-3 and Hematopoiesis,” in:Interleukins: Molecular Biology and Immunology, Kishimoto, T., ed., Karger, Basel, pp. 65-106 (1992).
Ihle, J.N. and D. Askew, “Origins and Properties of Hematopoietic Growth Factor-Dependent Cell Lines,”Int. J. Cell Cloning 7(2):68-91 AlphaMed Press (1989).
Ihle, J.N., “Cytokine receptor signalling,”Nature 377:591-594, Macmillan Publishers Ltd. (Oct. 1995).
Ip, N.Y. et al., “CNTF and LIF Act on Neuronal Cells via Shared Signaling Pathways That Involve the IL-6 Signal Transducing Receptor Component sp130,”Cell 69:1121-1132, MIT Press (Jun. 1992).
Igfort, R.J. et al., “Interleukin 3 binds to a 140-kDa phosphotyrosine-containing cell surface protein,”Proc. Natl. Acad. Sci. USA 85:7982-7986, National Academy of Sciences of the USA (1988).
Kappel, C.A. et al., “Regulating gene expression in transgenic animals,”Curr. Opin. Biotech. 3:548-553, Current Biology Ltd. (Oct. 1992).
Koch, C.A. et al., “SH2 and SH3 Domains: Elements That Control Interactions of Cytoplasmic Signaling Proteins,”Science 252:668-674, Association for the Advancement of Science (1991).
Linnekin, D. et al., “Association of the erythropoietin receptor with protein tyrosine kinase activity,”Proc. Natl. Acad. Sci. USA 89:6237-6241, National Academy of Sciences of the USA (Jul. 1992).
Linnekin, D. and W.L. Farrar, “Signal transduction of human interleukin 3 and granulocyte-macrophage colony-stimulating factor through serine and tyrosine phosphorylation,”Biochem. J. 271:317-324, London Portland Press on Behalf Of The Biochemical Society (1990).
Maliazewski, C.R. and W.C. Fanslow, “Soluble receptors for


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