Iummunoassay involving agglutination

Details Iummunoassay involving agglutination Iummunoassay involving agglutination

1980-02-26

1981-07-21

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

23230A, 23915, 252408, 422 57, 424 1, 424 8, 424 12, 435 7, G01N 3354, G01N 3356, G01N 3358

Patent

active

042796172

ABSTRACT:
A particle agglutination assay for antigens, antibodies and other binding proteins such as rheumatoid factor, uses two different, microscopic or submicroscopic particulate reagents. The first particulate reagent binds with the antigen or antibody under assay, and then the second particulate reagent is added which binds only to those first reagent particles which have bound to the antigen or antibody under assay, so causing agglutination. The free unbound first or second particles are assayed to indicate the presence and/or amount of the antigen or antibody under assay. The assay of rheumatoid factor may be so conducted to reveal the fractions of each immunoglobulin class of RF present. The assay is particularly useful for small quantities of antibodies present in human sera indicating allergy, infection or autoimmune diseases.

REFERENCES:
patent: 4092114 (1978-05-01), Buck
patent: 4102990 (1978-05-01), Uzgiris
patent: 4138213 (1979-02-01), Masson
patent: 4141965 (1979-02-01), Soothill
patent: 4162895 (1979-07-01), Cambiaso
patent: 4169138 (1979-09-01), Jonsson
patent: 4185084 (1980-01-01), Mochida
patent: 4189466 (1980-02-01), Ainis
patent: 4210622 (1980-07-01), Soothill

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