IUD Arrangement

Details IUD Arrangement IUD Arrangement

1980-07-02

1982-11-16

Howell, Kyle L.

Surgery

Truss

Pad

128260, A61F 546

Patent

active

043590462

ABSTRACT:
A medicated intrauterine device insertable in and retained in the uterus for a predetermined time period and having a drug with a controlled release rate and said drug comprising a guanidine such as an aromatic monoguanidine, an aromatic diguanidine, a non-aromatic monoguanidine or a non-aromatic diguanidine to provide anti-fibrinolytic, anti-proteolytic and/or anti-conceptive action. The drug is one or a mixture of more than one of such guanidines, or a mixture of one or more of such guanidines with one or more amidines.

REFERENCES:
patent: 4016251 (1977-04-01), Higuchi et al.
patent: 4144317 (1979-03-01), Higuchi et al.
patent: 4155991 (1979-05-01), Schopflin et al.
patent: 4180064 (1979-12-01), Heller et al.
patent: 4215200 (1980-07-01), Miyata et al.
"The Inhibition of Urokinase by Aromatic Diamidines", Thrombos. Diathes. Haemorrh, (Stuttg.), Geratz et al., 1975.
"Inhibition of the Amidase and Kininogenase Activities of Pancreatic Kallikrein", Arch. Int. Pharmacodyn., 194, Geratz et al., 1971.
"Problem Bleeding with IUD's", J. J., Wheeler et al., 1974.
"Vascular Defects in Human Endometrium Caused by IUD's", Contraception, vol. 16, No. 5, Hohman et al., Nov. 1977.
"Ultrastructural Hemostasis in Response to Vascular Injury Induced by IUD's", Thromb. Research, vol. 12, Hohman et al., 1978.
"World Health Organization, Expanded Programme of Research, Development and Research Training in Human Reproduction", Fifth Annual Report, Nov. 1976.
"Intrauterine Medication with Epsilon Aminocaproic Acid", Contraception, 11:395, Shaw et al., 1975.
"Comparitive Studies of the Inhibition of Trypsin, Plasmin, and Thrombin", European J. Biochem., 6 (1968), Markwardt et al., pp. 502-506.
"Inhibition of the Amidase and Kininogenase Activities by Aromatic Diamidines", Arch. Int. Pharmacodyn 194, Geratz et al., 1971.
"Inhibitory Effect of Aromatic Diamidines on Trypsin and Enterokinase", Experientia, 25/12, Geratz, 1969.
"Uterine Bleeding in the Rhesus Monkey in Response to Various Designs of IUD's", Fert. Steril., 25(4):358, Shaw et al., 1974.
"Studies on Menstrual Blood Loss in Intact and Experimental Rhesus Monkeys", J. Med. Prim., 2:153, Poon et al., 1973.
"Inhibition of Thrombin, Plasmin, Plasminogen Activation by Amidino Compounds", Throm. Diath. Haemorrh., 23(3):486-499, Geratz, 1970.
"Inhibition of Coagulation and Fibrinolysis by Aromatic Amidino Compounds", Theomb. Diath. Haemorrh., 25:391, Geratz, 1971.
"Fibrin Proteolysis in the Monkey Uterine Cavity", Nature 228:1097, Shaw et al., 1970.
"Effect of Tranexamic Acid in Menorrhagia with IUD's", J. Reprod. Med., 5:154, Westrom et al., 1970.
"Aminocaproic Acid and Menstrual Loss in Women Using IUD's", Brit. Med. J., 4:17-19, Kasonde et al., 1975.
"Studies of Menstrual Physiology", Medical Primatology, Shaw et al., Lyon, 1972, pp. 317-324.
"Effect of Ethamsylate and Aminocaproic Acid on Menstrual Blood Loss in Women Using IUD's", Brit. Med. J., Kasonde et al., Oct. 1975.
"Synthetische Hemmstoffe des Plasmins", Fibrinolyse, Landmann, Budapest, 1969.
"Comparitive Inhibition of Thrombin, Plasmin, Trypsin", J. Med. Chem., vol. 16, Coats, 1973.
"Structure-Activity Relationships for the Inhibition of Plasmin and Plasminogen Activation", Thrombos. Diathes. Haemorrh., (Stuttg), Geratz, 1973.
"Synthetic Enzyme Inhibitors as Antifertility Agents", Zanefeld, Fed. Eur. Biochem. Soc., 1970, 11(5), 345-347.
"Hemmung der Thrombin-, Plasmin-und Trypsinwirkungdurch Alkyl-und Alkoxybenzamidine", Markwardt et al., Berlin DD, pp. 551-554.
"Unlisted Drugs", vol. 24, #4, Catham, N. J., U.S., 1972, p. 57, Abstracts.
"Synthese Antiproteolytisch wirksamer Ester von Guanidinobenzoesauren und Guanidino Methylbenzosauren", Wagner et al., Beresch Pharm. Chem., 1973.
"Unlisted Drugs", Apr. 1972, vol. 24, No. 4, Catham, N.J., U.S., ABS.

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